People frequently ask me why the $%^# I decided to ‘get my genes done.’ I get the feeling that this is a scary area for many of us and that is part of the reason why I did it, to explore something that has an interesting future possibly. I also thought it would be a good idea to both understand where I’m from, genetically, and what possible risks lie ahead for me. Finally, 23andMe offered a DNA-day special a few weeks back and the price was right for me to do it.

For those that don’t know, 23andMe is a company who’s mission statement it is to develop new methods and technologies that will enable consumers to understand their own genetic information (source: Wikipedia). It has made headlines because Google invested in the company and one of the co-founders of 23andMe is married to one of the co-founders of Google.

In the following review, I want to write about several things: the last mile, which is a concept I discussed in my last blog post; the analysis; and finally, about whether it means anything.

The Last Mile
I previously wrote how crucial this concept is to running a successful business because 99.9999% of customers pay a business to get not only a product, but none of the headaches associated with getting this product—they don’t want to spend time making bank-transfers, physically going to a store to buy it (debatable), physically carrying the product home, reading complicated manuals. They just want to use it! Taking care of the last mile means that you can charge 2x or 10x for a product because the last mile is simply part of the product.

That 23andMe takes care of the last mile was very apparent to me in the context of the discount I received and the fact that live in Europe. If I remembered correctly, they discounted ca. 80% of the price of the product, but the non-discounted shipping costs of getting a ‘spit-vial’ to my home and back again to their labs was more expensive than the price of the product. It made me think twice about doing this, but in the end the result was that I had a pretty perfect service that required nothing from my part except:

1. paying,
2. waiting for delivery,
3. spitting into a vial,
4. filling out the Fedex papers,
5. sending it off,
6. and waiting for the results.

The total process took ca. 6 weeks, and while I’m not a particularly big fan of the shipping process in general, it was pretty comfortable on a whole.

Once the lab-analysis is done, you receive a mail notifying you that you’re results are ready, which you can access on the 23andMe website. Nothing wrong with that, except I hope that they use the dynamic nature of the web to keep updating info about my genes as their understanding of genetics improves. As I find it unlikely that people will do this analysis very frequently, I consider me not having to retake the test to get a marginal improvement in results a ‘last mile’ service as well. But we’ll see…

The Analysis
It’s important to state that ‘while you wait,’ there’s plenty to do on the site other than seeing your results, which frankly requires some (4-6 weeks after sending) patience to arrive. There are endless surveys you can take, forum-discussions, and articles. The whole thing feels like a Wikipedia for genetics, written in a clear format that even dumbos like me can understand. It does require time and interest in the matter.

The actual data that you get from the analysis is split into health results and ancestry results. Of these two, I found the ancestry part the least useful, even though I consider my personal ancestral history to be quite mixed and thus, for some, fascinating. Things you can do there is find out your maternal and paternal ancestry, find relatives (so far, completely useless, probably because most 23andMe users are American), and see visual representations of your geographic ancestry. I appear to be 100% European and resemble Northern Europeans the most, but the site also writes that “all humans are more than 99% similar to each other genetically,” so I’m not sure how significant or interesting this is.

The health results are much more interesting and for obvious reasons I will not go into great depth about my own results. The results are split into five categories, ‘Disease Risk,’ ‘Carrier Status,’ ‘Drug Response,’ ‘Traits,’ as well as a category, called ‘Health Labs,’ which goes into more experimental data. For some results, specifically carrier status and drug response, I feel like it’s a list I need to discuss with a doctor, as a lot of terms are quite scientific and it would require considerable time to understand what is relevant and what isn’t.

Most interesting to me is ‘Disease Risk,’ as it identifies areas to watch out for in the future and areas that are of less concern, and ‘Traits,’ which tells me stuff about lactose intolerance, muscle type, etc., all of which are handy to know in everyday life. Regarding Disease Risk, I like that they hide more serious conditions, until you specifically give permission to see these results. I was a little nervous about finding out exactly about those conditions, so I was happy the site allowed me some time to prepare myself mentally before seeing “the truth” (as far as that can be determined through such an analysis).

Does it mean anything?
Will you be able to live life without knowing these results? Clearly, we have survived for a long time without knowing much/anything about our genes and plenty of people today live on just fine in ignorant bliss. I have also lived my life in relative ignorance so far, though through years of playing around with exercise and diet, I realise that healthy living certainly benefits my current life and hopefully leads to a longer one (the analysis incidentally also shows your odds of living a certain age).

While frightening to find out whether you have an elevated chance of dying from things like cancer or getting Parkinson disease, I was relieved to find out about my chances, good or bad. Information means that you can prepare yourself, whether it’s just the idea that we are all mortal in some ways or that you have a checklist to visit your doctor with. I think my family will also be interested in finding out what my ancestry information reveals, though I didn’t think that part was particularly detailed.

Finally, while I’m a believer that no matter how well we understand ourselves, the chances of humanity as a species destroying itself or our planet destroying us are much more significant, I still think that we have for some years been on the threshold of a genetic revolution, one that will very likely result in things like a much longer and healthier life, though not without some significant societal consequences such as how to support an ageing population.

Just like the Apple iPad could potentially revolutionise computing and it’s good a reason for buying one, I consider the ‘plug-and-play’ 23andMe service to be a worthwhile purchase to gain a better understanding of where we stand in terms of the revolution in medicine.

Marks out of 10 – Service: 7/10 (points taken off for the time it took to find out the results); Analysis & presentation: 8/10 (points taken off for ancestry & complexity of certain health information); Overall Usefulness: 6/10 (you can live without it, not sure how doctors will react to this, more targeted at US than elsewhere); Overall grade: 7/10.

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